| 1-May | ChC | Murton, Matt | - Optioned to minors |
| 38 | 24 |
| 1-May | ChC | Soriano, Alfonso | + Activated from 15-day DL |
| 38 | 25 |
| 1-May | Hou | Cassel, Jack | - Optioned to minors |
| 35 | 24 |
| 1-May | Hou | Wigginton, Ty | + Activated from 15-day DL |
| 35 | 25 |
| 1-May | LAA | Izturis, Maicer | - Placed on 15-day DL |
| 40 | 23 |
| 1-May | LAA | Escobar, Kelvim | - Transferred to 60-day DL |
| 39 | 23 |
| 1-May | LAA | Adenhart, Nick | + Purchased from minors |
| 40 | 24 |
| 1-May | Min | Buscher, Brian | - Optioned to minors |
| 38 | 24 |
| 1-May | Min | Everett, Adam | + Activated from 15-day DL |
| 38 | 25 |
| 1-May | NYM | Molina, Gustavo | - Optioned to minors |
| 37 | 24 |
| 1-May | NYM | Alou, Moises | + Activated from 15-day DL |
| 37 | 25 |
| 1-May | NYY | Hughes, Phil | - Placed on 15-day DL |
| 40 | 24 |
| 1-May | SF | Alfonzo, Eliezer | - Suspended | 50 games | 40 | 25 |
| 1-May | Tex | Jennings, Jason | - Injured |
| 40 | 24 |
| 2-May | Atl | Lillibridge, Brent | - Optioned to minors |
| 40 | 24 |
| 2-May | Atl | Reyes, Jo-Jo | + Recalled from minors |
| 40 | 25 |
| 2-May | Bal | Bierd, Randor | - Placed on 15-day DL |
| 38 | 24 |
| 2-May | Bal | Cormier, Lance | + Purchased from minors |
| 39 | 25 |
| 2-May | ChC | Hart, Kevin | - Optioned to minors |
| 38 | 24 |
| 2-May | ChC | Mateo, Juan | - Waived |
| 37 | 24 |
| 2-May | ChC | Fox, Chad | + Purchased from minors |
| 38 | 25 |
| 2-May | ChW | Ramirez, Alexei | - Placed on restricted list |
| 39 | 24 |
| 2-May | ChW | Russell, Adam | + Recalled from minors |
| 39 | 25 |
| 2-May | Col | Tulowitzki, Troy | - Placed on 15-day DL |
| 38 | 24 |
| 2-May | Col | de la Rosa, Jorge | + Purchased from minors |
| 39 | 25 |
| 2-May | Fla | Willingham, Josh | - Placed on 15-day DL |
| 40 | 24 |
| 2-May | Fla | Carroll, Brett | + Recalled from minors |
| 40 | 25 |
| 2-May | LAA | Brown, Matt | - Optioned to minors |
| 40 | 23 |
| 2-May | LAA | Willits, Reggie | + Recalled from minors |
| 40 | 25 |
| 2-May | Mil | Gallardo, Yovani | - Placed on 15-day DL |
| 38 | 24 |
| 2-May | Mil | Turnbow, Derrick | - Waived |
| 37 | 23 |
| 2-May | Mil | Dillon, Joe | + Recalled from minors |
| 37 | 24 |
| 2-May | Mil | Bush, Dave | + Recalled from minors |
| 37 | 25 |
| 2-May | NYY | Veras, Jose | + Recalled from minors |
| 40 | 25 |
| 2-May | TB | Glover, Gary | - Placed on 15-day DL |
| 40 | 24 |
| 2-May | TB | Ruggiano, Justin | + Recalled from minors |
| 40 | 25 |
| 2-May | Tex | Jennings, Jason | - Placed on 15-day DL |
| 40 | 24 |
| 2-May | Tex | Murray, AJ | + Recalled from minors |
| 40 | 25 |
| 2-May | Was | Cordero, Chad | - Placed on 15-day DL |
| 37 | 24 |
| 2-May | Was | LoDuca, Paul | + Activated from 15-day DL |
| 37 | 25 |
| 3-May | Bos | Moss, Brandon | - Injured |
| 39 | 24 |
| 3-May | ChC | Hill, Rich | - Optioned to minors |
| 38 | 24 |
| 3-May | ChC | Gallagher, Sean | + Recalled from minors |
| 38 | 25 |
| 3-May | Det | Bautista, Denny | - Placed on 15-day DL |
| 35 | 24 |
| 3-May | Det | Dolsi, Freddy | + Purchased from minors |
| 36 | 25 |
| 3-May | LAD | LaRoche, Andy | + Activated from 15-day DL | and optioned | 40 | 25 |
| 3-May | Pit | Astacio, Olivo | - Released |
| 37 | 25 |
| 4-May | LAA | Figgins, Chone | - Injured |
| 40 | 24 |
| 4-May | LAA | Moseley, Dustin | - Placed on 15-day DL |
| 40 | 23 |
| 4-May | LAA | Rodriguez, Sean | + Recalled from minors |
| 40 | 24 |
| 4-May | LAD | Loaiza, Esteban | - Injured |
| 40 | 24 |
| 4-May | Min | Baker, Scott | - Injured |
| 38 | 24 |
| 4-May | NYY | Kennedy, Ian | - Optioned to minors |
| 40 | 24 |
| 4-May | NYY | Bruney, Brian | - Transferred to 60-day DL |
| 39 | 24 |
| 4-May | NYY | Rasner, Darrell | + Purchased from minors |
| 40 | 25 |
| 4-May | Pit | Meek, Evan | - Returned via Rule V |
| 36 | 24 |
| 4-May | Pit | Burnett, Sean | + Purchased from minors |
| 37 | 25 |
| 4-May | StL | Reyes, Anthony | - Optioned to minors |
| 40 | 24 |
| 4-May | StL | Parisi, Mike | + Recalled from minors |
| 40 | 25 |
| 4-May | TB | Ruggiano, Justin | - Optioned to minors |
| 40 | 24 |
| 4-May | TB | Kazmir, Scott | + Activated from 15-day DL |
| 40 | 25 |
| 5-May | Atl | Pena, Brayan | - Injured |
| 40 | 24 |
| 5-May | Atl | Prado, Martin | - Placed on 15-day DL |
| 40 | 23 |
| 5-May | Atl | Moylan, Peter | - Transferred to 60-day DL |
| 39 | 23 |
| 5-May | Atl | Norton, Greg | + Acquired from | waivers | 40 | 24 |
| 5-May | Bos | Moss, Brandon | - Placed on 15-day DL |
| 39 | 24 |
| 5-May | Bos | Hansen, Craig | + Recalled from minors |
| 39 | 25 |
| 5-May | Cin | Bray, Bill | - Optioned to minors |
| 40 | 24 |
| 5-May | Cin | Weathers, David | + Activated from 15-day DL |
| 40 | 25 |
| 5-May | Det | Jones, Jacque | - Waived |
| 35 | 24 |
| 5-May | Det | Joyce, Matt | + Purchased from minors |
| 36 | 25 |
| 6-May | ChW | Russell, Adam | - Optioned to minors |
| 39 | 24 |
| 6-May | ChW | Ramirez, Alexei | + Activated from restricted list |
| 39 | 25 |
| 6-May | Cin | Mercker, Kent | - Injured |
| 40 | 24 |
| 6-May | Cle | Michaels, Jason | - Waived |
| 39 | 24 |
| 6-May | Cle | Francisco, Ben | + Recalled from minors |
| 39 | 25 |
| 6-May | LAD | Furcal, Rafael | - Injured |
| 40 | 24 |
| 6-May | NYY | Gonzalez, Alberto | - Optioned to minors |
| 40 | 24 |
| 6-May | NYY | Betemit, Wilson | + Activated from 15-day DL |
| 40 | 25 |
| 7-May | Col | Newman, Josh | - Optioned to minors |
| 39 | 24 |
| 7-May | Col | Arias, Alberto | + Purchased from minors |
| 40 | 25 |
| 7-May | Oak | Denorfia, Chris | - Injured |
| 40 | 24 |
| 7-May | SD | Cameron, Kevin | - Injured |
| 38 | 24 |
| 7-May | Tor | Eckstein, David | - Injured |
| 39 | 24 |
| 7-May | Tor | McDonald, John | - Injured |
| 39 | 23 |
| 8-May | Atl | Pena, Brayan | - Placed on 15-day DL |
| 40 | 24 |
| 8-May | Atl | Infante, Omar | + Activated from 15-day DL |
| 40 | 25 |
| 8-May | Bal | Torres, Eider | - Optioned to minors |
| 39 | 24 |
| 8-May | Bal | Bynum, Freddie | + Recalled from minors |
| 39 | 25 |
| 8-May | Min | Baker, Scott | - Placed on 15-day DL |
| 38 | 24 |
| 8-May | Min | Slowey, Kevin | + Activated from 15-day DL |
| 38 | 25 |
| 8-May | Pit | Michaels, Jason | + Acquired from | waivers | 38 | 25 |
| 8-May | SD | Cameron, Kevin | - Placed on 15-day DL |
| 38 | 24 |
| 8-May | SD | Estes, Shawn | + Purchased from minors |
| 39 | 25 |
| 8-May | SF | Hennessey, Brad | - Optioned to minors |
| 40 | 24 |
| 8-May | SF | Sadler, Billy | + Recalled from minors |
| 40 | 25 |
| 8-May | Tex | Murray, AJ | - Optioned to minors |
| 40 | 24 |
| 8-May | Tex | Broussard, Ben | - Waived |
| 39 | 23 |
| 8-May | Tex | Metcalf, Travis | + Activated from 15-day DL |
| 39 | 24 |
| 8-May | Tex | Gabbard, Kason | + Activated from 15-day DL |
| 39 | 25 |
| 8-May | Tor | Lind, Adam | - Optioned to minors |
| 39 | 22 |
| 8-May | Tor | Eckstein, David | - Placed on 15-day DL |
| 39 | 22 |
| 8-May | Tor | McDonald, John | - Placed on 15-day DL |
| 39 | 22 |
| 8-May | Tor | Velandia, Jorge | + Purchased from minors |
| 40 | 23 |
| 8-May | Tor | Inglett, Joe | + Recalled from minors |
| 40 | 24 |
| 9-May | Atl | Carlyle, Buddy | - Injured |
| 40 | 24 |
| 9-May | ChC | Marshall, Sean | - Optioned to minors |
| 38 | 24 |
| 9-May | ChC | Eyre, Scott | + Activated from 15-day DL |
| 38 | 25 |
| 9-May | Cin | Mercker, Kent | - Placed on 15-day DL |
| 40 | 24 |
| 9-May | Cin | Bray, Bill | + Recalled from minors |
| 40 | 25 |
| 9-May | LAD | Loiaza, Esteban | - Placed on 15-day DL |
| 40 | 23 |
| 9-May | LAD | Brazoban, Yhency | + Recalled from minors |
| 40 | 24 |
| 9-May | Min | Neshek, Pat | - Placed on 15-day DL |
| 38 | 24 |
| 9-May | Min | Perkins, Glen | + Recalled from minors |
| 38 | 25 |
| 9-May | NYM | Casanova, Raul | - Waived |
| 36 | 24 |
| 9-May | NYM | Castro, Ramon | + Activated from 15-day DL |
| 36 | 25 |
| 9-May | NYY | Britton, Chris | - Optioned to minors |
| 40 | 24 |
| 9-May | NYY | Farnsworth, Kyle | - Suspended | 1 game | 40 | 23 |
| 9-May | NYY | Igawa, Kei | + Recalled from minors |
| 40 | 24 |
| 9-May | Oak | Braden, Dallas | - Optioned to minors |
| 40 | 23 |
| 9-May | Oak | Foulke, Keith | + Activated from 15-day DL |
| 40 | 24 |
| 9-May | Phi | Harman, Brad | - Optioned to minors |
| 36 | 24 |
| 9-May | Phi | Rollins, Jimmy | + Activated from 15-day DL |
| 36 | 25 |
| 9-May | Pit | Morgan, Nyjer | - Optioned to minors |
| 38 | 24 |
| 9-May | Pit | Michaels, Jason | + Added to 25-man roster |
| 38 | 25 |
| 9-May | SD | Morton, Colt | - Optioned to minors |
| 39 | 24 |
| 9-May | SD | Edmonds, Jim | - Released |
| 38 | 23 |
| 9-May | SD | Henn, Sean | + Acquired from | waivers | 39 | 23 |
| 9-May | SD | Carlin, Luke | + Purchased from minors |
| 40 | 24 |
| 9-May | SD | Gerut, Jody | + Recalled from minors |
| 40 | 25 |
| 9-May | TB | Haynes, Nathan | - Waived |
| 40 | 24 |
| 9-May | TB | Floyd, Cliff | + Activated from 15-day DL |
| 40 | 25 |
| 9-May | Tor | Inglett, Joe | - Optioned to minors |
| 40 | 23 |
| 9-May | Tor | Chacin, Gustavo | - Waived |
| 39 | 23 |
| 9-May | Tor | Santos, Sergio | - Waived |
| 38 | 23 |
| 9-May | Tor | Mench, Kevin | + Purchased from minors |
| 39 | 24 |
| 9-May | Tor | Wilkerson, Brad | + Signed |
| 40 | 25 |
| 9-May | Was | Estrada, Johnny | - Placed on 15-day DL |
| 37 | 24 |
| 9-May | Was | LoDuca, Paul | - Placed on 15-day DL |
| 37 | 23 |
| 9-May | Was | Dukes, Elijah | + Activated from 15-day DL |
| 37 | 24 |
| 9-May | Was | Flores, Jesus | + Recalled from minors |
| 37 | 25 |
| 10-May | Atl | Carlyle, Buddy | - Placed on 15-day DL |
| 40 | 24 |
| 10-May | Atl | James, Chuck | + Recalled from minors |
| 40 | 25 |
| 10-May | LAA | Figgins, Chone | - Placed on 15-day DL |
| 40 | 24 |
| 10-May | LAA | Morales, Kendry | + Recalled from minors |
| 40 | 25 |
| 10-May | NYY | Albaladejo, Jonathan | - Placed on 15-day DL |
| 40 | 23 |
| 10-May | NYY | Britton, Chris | + Recalled from minors |
| 40 | 24 |
| 10-May | NYY | Farnsworth, Kyle | + Reinstated |
| 40 | 25 |
| 10-May | Oak | Buck, Travis | + Activated from 15-day DL | and optioned | 40 | 24 |
| 10-May | SD | Rusch, Glendon | - Outrighted to minors |
| 39 | 24 |
| 10-May | SD | Henn, Sean | + Added to 25-man roster |
| 39 | 25 |
| 10-May | Sea | Sexson, Richie | - Suspended | 5 games | 38 | 24 |
| 10-May | SF | Bocock, Brian | - Optioned to minors |
| 40 | 24 |
| 10-May | SF | Vizquel, Omar | + Activated from 15-day DL |
| 40 | 25 |
| 10-May | Tor | Wells, Vernon | - Placed on 15-day DL |
| 40 | 24 |
| 10-May | Tor | Accardo, Jeremy | - Placed on 15-day DL |
| 40 | 23 |
| 10-May | Tor | Thorpe, Tracy | - Waived |
| 39 | 23 |
| 10-May | Tor | Benitez, Armando | + Purchased from minors |
| 40 | 24 |
| 10-May | Tor | Inglett, Joe | + Recalled from minors |
| 40 | 25 |
| 11-May | Bal | McCrory, Bob | - Optioned to minors |
| 39 | 24 |
| 11-May | Bal | Cintron, Alex | + Purchased from minors |
| 40 | 25 |
| 11-May | Bos | Lowrie, Jed | - Optioned to minors |
| 39 | 24 |
| 11-May | Bos | Cora, Alex | + Activated from 15-day DL |
| 39 | 25 |
| 11-May | Cle | Mastny, Tom | - Optioned to minors |
| 39 | 24 |
| 11-May | Cle | Tyner, Jason | + Purchased from minors |
| 40 | 25 |
| 11-May | Col | Redman, Mark | - Outrighted to minors |
| 39 | 24 |
| 11-May | Col | Reynolds, Greg | + Purchased from minors |
| 40 | 25 |
| 11-May | Min | Punto, Nick | - Placed on 15-day DL |
| 38 | 24 |
| 11-May | Min | Casilla, Alexei | + Recalled from minors |
| 38 | 25 |
| 11-May | NYY | Betemit, Wilson | - Placed on 15-day DL |
| 40 | 24 |
| 11-May | NYY | Gonzalez, Alberto | + Recalled from minors |
| 40 | 25 |
| 11-May | Oak | Denorfia, Chris | - Placed on 15-day DL |
| 40 | 24 |
| 11-May | Oak | Harden, Rich | + Activated from 15-day DL |
| 40 | 25 |
| 11-May | SD | Thatcher, Joe | - Optioned to minors |
| 39 | 24 |
| 11-May | SD | Corey, Bryan | + Purchased from minors |
| 40 | 25 |
| 11-May | TB | Birkins, Kurt | - Optioned to minors |
| 40 | 24 |
| 11-May | TB | Glover, Gary | + Activated from 15-day DL |
| 40 | 25 |
| 11-May | Tex | Fukumori, Kazuo | - Outrighted to minors |
| 38 | 25 |
| 11-May | Tex | Millwood, Kevin | - Placed on 15-day DL |
| 38 | 24 |
| 11-May | Tex | Mathis, Doug | + Purchased from minors |
| 39 | 25 |
| 11-May | Was | O'Connor, Mike | - Optioned to minors |
| 37 | 24 |
| 11-May | Was | Schroder, Chris | + Recalled from minors |
| 37 | 25 |
| 12-May | Bos | Tavarez, Julian | - Waived |
| 38 | 24 |
| 12-May | Bos | Casey, Sean | + Activated from 15-day DL |
| 38 | 25 |
| 12-May | ChC | Fox, Chad | - Injured |
| 38 | 24 |
| 12-May | Col | Speier, Ryan | - Injured |
| 40 | 24 |
| 12-May | LAA | Wood, Brandon | - Optioned to minors |
| 40 | 24 |
| 12-May | LAA | Brown, Matt | + Recalled from minors |
| 40 | 25 |
| 12-May | SD | Crabbe, Callix | - Returned via Rule V |
| 39 | 24 |
| 12-May | SD | Gonzalez, Edgar | + Purchased from minors |
| 40 | 25 |
| 12-May | TB | Cannizaro, Andy | - Waived |
| 39 | 24 |
| 12-May | TB | Zobrist, Ben | + Activated from 15-day DL |
| 39 | 25 |
| 13-May | Bos | Buchholz, Clay | - Injured |
| 38 | 24 |
| 13-May | LAA | Adenhart, Nick | - Optioned to minors |
| 40 | 24 |
| 13-May | LAA | O'Day, Darren | - Optioned to minors |
| 40 | 23 |
| 13-May | LAA | Izturis, Maicer | + Activated from 15-day DL |
| 40 | 24 |
| 13-May | LAA | Arredondo, Jose | + Recalled from minors |
| 40 | 25 |
| 13-May | LAD | Furcal, Rafael | - Placed on 15-day DL |
| 40 | 24 |
| 13-May | LAD | Abreu, Tony | - Transferred to 60-day DL |
| 39 | 24 |
| 13-May | LAD | Maza, Luis | + Purchased from minors |
| 40 | 25 |
| 13-May | NYM | Pagan, Angel | - Placed on 15-day DL |
| 36 | 24 |
| 13-May | NYM | Figueroa, Nelson | - Waived |
| 35 | 23 |
| 13-May | NYM | Sosa, Jorge | - Waived |
| 34 | 22 |
| 13-May | NYM | Wise, Matt | + Activated from 15-day DL |
| 34 | 23 |
| 13-May | NYM | Tatis, Fernando | + Purchased from minors |
| 35 | 24 |
| 13-May | NYM | Vargas, Claudio | + Purchased from minors |
| 36 | 25 |
| 13-May | Pit | VanBenschoten, John | - Optioned to minors |
| 38 | 24 |
| 13-May | Pit | Salas, Marino | + Purchased from minors |
| 39 | 25 |
| 14-May | Bos | Buchholz, Clay | - Placed on 15-day DL |
| 38 | 24 |
| 14-May | Bos | Van Every, Jon | + Recalled from minors |
| 38 | 25 |
| 14-May | ChC | Ward, Daryle | - Injured |
| 38 | 23 |
| 14-May | Cin | Keppinger, Jeff | - Placed on 15-day DL |
| 40 | 24 |
| 14-May | Cin | Janish, Paul | + Recalled from minors |
| 40 | 25 |
| 14-May | Col | Speier, Ryan | - Placed on 15-day DL |
| 40 | 24 |
| 14-May | Col | Newman, Josh | + Recalled from minors |
| 40 | 25 |
| 14-May | LAA | Morales, Kendry | - Optioned to minors |
| 40 | 24 |
| 14-May | LAA | Lackey, John | + Activated from 15-day DL |
| 40 | 25 |
| 14-May | Oak | Brown, Andrew | - Injured |
| 40 | 24 |
| 14-May | Pit | Doumit, Ryan | - Placed on 15-day DL |
| 39 | 24 |
| 14-May | Pit | Chavez, Raul | + Purchased from minors |
| 40 | 25 |
| 14-May | SF | Valdez, Merkin | - Injured |
| 40 | 24 |
| 14-May | TB | Dohmann, Scott | - Waived |
| 38 | 24 |
| 14-May | TB | Reyes, Al | + Activated from 15-day DL |
| 38 | 25 |
| 14-May | Tex | Metcalf, Travis | - Optioned to minors |
| 39 | 24 |
| 14-May | Tex | Byrd, Marlon | + Activated from 15-day DL |
| 39 | 25 |
| 15-May | ChC | Pie, Felix | - Optioned to minors |
| 38 | 22 |
| 15-May | ChC | Edmonds, Jim | + Signed |
| 39 | 23 |
| 15-May | NYY | Igawa, Kei | - Optioned to minors |
| 40 | 24 |
| 15-May | NYY | Kennedy, Ian | + Recalled from minors |
| 40 | 25 |
| 15-May | SD | Peavy, Jake | - Injured |
| 40 | 24 |
| 15-May | SF | Valdez, Merkin | - Placed on 15-day DL |
| 40 | 24 |
| 15-May | SF | Frandsen, Kevin | - Transferred to 60-day DL |
| 39 | 24 |
| 15-May | SF | Hinshaw, Alex | + Purchased from minors |
| 40 | 25 |
| 15-May | Was | Schroder, Chris | - Optioned to minors |
| 37 | 24 |
| 15-May | Was | Bergmann, Jason | + Recalled from minors |
| 37 | 25 |
| 16-May | Atl | James, Chuck | - Optioned to minors |
| 40 | 24 |
| 16-May | Atl | Stockman, Phil | + Recalled from minors |
| 40 | 25 |
| 16-May | ChW | Uribe, Juan | - Injured |
| 39 | 24 |
| 16-May | Cle | Tyner, Jason | - Waived |
| 39 | 24 |
| 16-May | Cle | Sowers, Jeremy | + Recalled from minors |
| 39 | 25 |
| 16-May | KC | Buck, John | - Placed on bereavement list |
| 39 | 24 |
| 16-May | KC | Tupman, Matt | + Recalled from minors |
| 39 | 25 |
| 16-May | Mil | Stetter, Mitch | - Optioned to minors |
| 37 | 24 |
| 16-May | Mil | Jackson, Zach | + Recalled from minors |
| 37 | 25 |
| 16-May | Min | Santos, Sergio | + Acquired from | waivers and optioned | 39 | 25 |
| 16-May | Oak | Casilla, Santiago | - Placed on 15-day DL |
| 40 | 23 |
| 16-May | Oak | Petit, Gregorio | + Recalled from minors |
| 40 | 24 |
| 16-May | Sea | Sexson, Richie | + Reinstated |
| 38 | 25 |
| 16-May | StL | Isringhausen, Jason | - Placed on 15-day DL |
| 40 | 24 |
| 16-May | StL | Kinney, Josh | - Transferred to 60-day DL |
| 39 | 24 |
| 16-May | StL | Perez, Chris | + Purchased from minors |
| 40 | 25 |
| 16-May | Tor | Velandia, Jorge | - Waived |
| 39 | 24 |
| 16-May | Tor | Purcey, David | + Recalled from minors |
| 39 | 25 |
| 16-May | Was | Belliard, Ronnie | - Injured |
| 37 | 24 |
| 16-May | Was | Johnson, Nick | - Placed on 15-day DL |
| 37 | 23 |
| 16-May | Was | Young, Dmitri | + Activated from 15-day DL |
| 37 | 24 |
| 17-May | Cle | Sowers, Jeremy | - Optioned to minors |
| 39 | 24 |
| 17-May | Cle | Aubrey, Michael | + Recalled from minors |
| 39 | 25 |
| 17-May | Hou | Geary, Geoff | - Placed on 15-day DL |
| 35 | 24 |
| 17-May | Hou | Nieve, Fernando | + Recalled from minors |
| 35 | 25 |
| 17-May | Mil | Riske, David | - Placed on 15-day DL |
| 37 | 24 |
| 17-May | Mil | Difelice, Mark | + Purchased from minors |
| 38 | 25 |
| 17-May | Min | Tolbert, Matt | - Placed on 15-day DL |
| 39 | 24 |
| 17-May | Min | Clark, Howie | + Purchased from minors |
| 40 | 25 |
| 17-May | Tor | Purcey, David | - Optioned to minors |
| 39 | 24 |
| 17-May | Tor | Luna, Hector | + Purchased from minors |
| 40 | 25 |
| 18-May | Bos | Van Every, Jon | - Optioned to minors |
| 38 | 24 |
| 18-May | Bos | Smith, Chris | + Purchased from minors |
| 39 | 25 |
| 18-May | ChC | Ward, Daryle | - Placed on 15-day DL |
| 39 | 23 |
| 18-May | ChC | Hoffpauir, Micah | + Purchased from minors |
| 40 | 24 |
| 18-May | Oak | Murphy, Donnie | - Injured |
| 40 | 23 |
| 18-May | Was | Kearns, Austin | - Injured |
| 37 | 23 |
| 19-May | ChC | Fox, Chad | - Placed on 15-day DL |
| 40 | 24 |
| 19-May | ChC | Ascanio, Jose | + Recalled from minors |
| 40 | 25 |
| 19-May | ChW | Perez, Oneli | - Waived |
| 38 | 24 |
| 19-May | Cle | Perez, Oneli | + Acquired from | waivers and optioned | 40 | 25 |
| 19-May | KC | Tupman, Matt | - Optioned to minors |
| 39 | 24 |
| 19-May | KC | Buck, John | + Activated from bereavement list |
| 39 | 25 |
| 19-May | Oak | Murphy, Donnie | - Placed on 15-day DL |
| 40 | 23 |
| 19-May | Oak | Braden, Dallas | + Recalled from minors |
| 40 | 24 |
| 19-May | Sea | Clement, Jeff | - Optioned to minors |
| 38 | 24 |
| 19-May | Sea | Thorpe, Tracy | + Acquired from | waivers and optioned | 39 | 24 |
| 19-May | Sea | Reed, Jeremy | + Recalled from minors |
| 39 | 25 |
| 20-May | Bos | Smith, Chris | - Optioned to minors |
| 39 | 24 |
| 20-May | Bos | Masterson, Justin | + Recalled from minors |
| 39 | 25 |
| 20-May | LAD | Bennett, Gary | - Placed on 15-day DL |
| 40 | 24 |
| 20-May | LAD | Schmidt, Jason | - Transferred to 60-day DL |
| 39 | 24 |
| 20-May | LAD | Ardoin, Danny | + Purchased from minors |
| 40 | 25 |
| 20-May | NYY | Britton, Chris | - Optioned to minors |
| 40 | 24 |
| 20-May | NYY | Rodriguez, Alex | + Activated from 15-day DL |
| 40 | 25 |
| 20-May | Oak | Brown, Andrew | - Placed on 15-day DL |
| 40 | 24 |
| 20-May | Oak | Dinardo, Lenny | + Recalled from minors |
| 40 | 25 |
| 20-May | SD | Peavy, Jake | - Placed on 15-day DL |
| 40 | 24 |
| 20-May | SD | Thatcher, Joe | + Recalled from minors |
| 40 | 25 |
| 20-May | Was | Belliard, Ronnie | - Placed on 15-day DL |
| 37 | 23 |
| 20-May | Was | Schroder, Chris | + Recalled from minors |
| 37 | 24 |
| 21-May | Bos | Masterson, Justin | - Optioned to minors |
| 39 | 24 |
| 21-May | Bos | Colon, Bartolo | + Purchased from minors |
| 40 | 25 |
| 21-May | Det | Rapada, Clay | - Placed on 15-day DL |
| 36 | 24 |
| 21-May | Det | Willis, Dontrelle | + Activated from 15-day DL |
| 36 | 25 |
| 21-May | LAA | Aybar, Erick | - Placed on 15-day DL |
| 40 | 24 |
| 21-May | LAA | Figgins, Chone | + Activated from 15-day DL |
| 40 | 25 |
| 21-May | Mil | Gagne, Eric | - Injured |
| 38 | 24 |
| 21-May | SF | Velez, Eugenio | - Optioned to minors |
| 40 | 24 |
| 21-May | SF | Denker, Travis | + Recalled from minors |
| 40 | 25 |
| 21-May | StL | Pineiro, Joel | - Injured |
| 40 | 24 |
| 21-May | Tex | German, Franklyn | - Waived |
| 38 | 24 |
| 21-May | Tex | Loe, Kameron | + Recalled from minors |
| 38 | 25 |
| 22-May | LAA | Figgins, Chone | - Injured |
| 40 | 24 |
| 22-May | LAA | Brown, Matt | - Optioned to minors |
| 40 | 23 |
| 22-May | LAA | Wood, Brandon | + Recalled from minors |
| 40 | 24 |
| 22-May | NYM | Alou, Moises | - Placed on 15-day DL |
| 36 | 24 |
| 22-May | NYM | Casanova, Raul | + Purchased from minors |
| 37 | 25 |
| 22-May | NYY | Karstens, Jeff | + Activated from 15-day DL | and optioned | 40 | 25 |
| 22-May | Sea | Baek, Cha Seung | - Waived |
| 38 | 24 |
| 22-May | Sea | Dickey, RA | + Recalled from minors |
| 38 | 25 |
| 23-May | Ari | Medders, Brandon | - Waived |
| 39 | 24 |
| 23-May | Ari | Davis, Doug | + Activated from 15-day DL |
| 39 | 25 |
| 23-May | Atl | Pena, Brayan | + Activated from 15-day DL | and waived | 39 | 25 |
| 23-May | Bal | Cherry, Rocky | + Activated from 15-day DL | and optioned | 40 | 25 |
| 23-May | ChW | Uribe, Juan | - Placed on 15-day DL |
| 38 | 24 |
| 23-May | ChW | Wise, DeWayne | + Purchased from minors |
| 39 | 25 |
| 23-May | Cle | Breslow, Craig | - Waived |
| 39 | 24 |
| 23-May | Cle | Borowski, Joe | + Activated from 15-day DL |
| 39 | 25 |
| 23-May | Fla | Andino, Robert | - Optioned to minors |
| 40 | 24 |
| 23-May | Fla | Wolf, Ross | - Waived |
| 39 | 24 |
| 23-May | Fla | Jones, Jacque | + Purchased from minors |
| 40 | 25 |
| 23-May | Mil | Gagne, Eric | - Placed on 15-day DL |
| 38 | 24 |
| 23-May | Mil | Dillard, Tim | + Recalled from minors |
| 38 | 25 |
| 23-May | Min | Everett, Adam | - Placed on 15-day DL |
| 40 | 24 |
| 23-May | Min | Macri, Matt | + Recalled from minors |
| 40 | 25 |
| 23-May | SD | Thatcher, Joe | - Optioned to minors |
| 40 | 24 |
| 23-May | SD | Young, Chris | - Placed on 15-day DL |
| 40 | 23 |
| 23-May | SD | Bard, Josh | - Placed on 15-day DL |
| 40 | 22 |
| 23-May | SD | Germano, Justin | - Waived |
| 39 | 21 |
| 23-May | SD | Adams, Mike | + Purchased from minors |
| 40 | 22 |
| 23-May | SD | Banks, Josh | + Recalled from minors |
| 40 | 23 |
| 23-May | SD | Morton, Colt | + Recalled from minors |
| 40 | 24 |
| 23-May | SD | Wells, Jared | + Recalled from minors |
| 40 | 25 |
| 23-May | Was | Chico, Matt | - Optioned to minors |
| 37 | 23 |
| 23-May | Was | Schroder, Chris | - Optioned to minors |
| 37 | 22 |
| 23-May | Was | Kearns, Austin | - Placed on 15-day DL |
| 37 | 22 |
| 23-May | Was | Wagner, Ryan | - Transferred to 60-day DL |
| 36 | 22 |
| 23-May | Was | Langerhans, Ryan | + Purchased from minors |
| 37 | 23 |
| 23-May | Was | Sanches, Brian | + Purchased from minors |
| 38 | 24 |
| 23-May | Was | Manning, Charlie | + Purchased from minors |
| 39 | 25 |
| 24-May | Bos | Moss, Brandon | + Activated from 15-day DL | and optioned | 40 | 25 |
| 24-May | Cle | Lewis, Jensen | - Optioned to minors |
| 39 | 24 |
| 24-May | Cle | Carmona, Fausto | - Placed on 15-day DL |
| 39 | 23 |
| 24-May | Cle | Elarton, Scott | + Purchased from minors |
| 40 | 24 |
| 24-May | Cle | Mujica, Edward | + Recalled from minors |
| 40 | 25 |
| 24-May | Col | Hawpe, Brad | - Placed on 15-day DL |
| 40 | 24 |
| 24-May | Col | Barmes, Clint | - Placed on 15-day DL |
| 40 | 23 |
| 24-May | Col | Smith, Seth | + Recalled from minors |
| 40 | 24 |
| 24-May | Col | Stewart, Ian | + Recalled from minors |
| 40 | 25 |
| 24-May | Fla | Carroll, Brett | - Placed on 15-day DL |
| 40 | 24 |
| 24-May | Fla | Andino, Robert | + Recalled from minors |
| 40 | 25 |
| 24-May | LAD | Brazoban, Yhency | - Optioned to minors |
| 40 | 24 |
| 24-May | LAD | Jones, Andruw | - Placed on 15-day DL |
| 40 | 23 |
| 24-May | LAD | Garciaparra, Nomar | - Transferred to 60-day DL |
| 39 | 23 |
| 24-May | LAD | Loaiza, Esteban | + Activated from 15-day DL | and waived | 38 | 23 |
| 24-May | LAD | Kershaw, Clayton | + Purchased from minors |
| 39 | 24 |
| 24-May | LAD | Tiffee, Terry | + Purchased from minors |
| 40 | 25 |
| 24-May | NYM | Anderson, Marlon | - Placed on 15-day DL |
| 37 | 24 |
| 24-May | NYM | Evans, Nick | + Purchased from minors |
| 38 | 25 |
| 24-May | Phi | Werth, Jayson | - Placed on 15-day DL |
| 36 | 24 |
| 24-May | Phi | Bohn, TJ | + Recalled from minors |
| 36 | 25 |
| 24-May | SD | Morton, Colt | - Optioned to minors |
| 40 | 24 |
| 24-May | SD | Barrett, Michael | + Activated from 15-day DL |
| 40 | 25 |
| 25-May | Col | Holliday, Matt | - Placed on 15-day DL |
| 40 | 24 |
| 25-May | Col | Sullivan, Cory | + Recalled from minors |
| 40 | 25 |
| 25-May | Fla | Andino, Robert | - Optioned to minors | between games of DH | 40 | 24 |
| 25-May | Fla | de la Cruz, Eulogio | + Recalled from minors | between games of DH | 40 | 25 |
| 25-May | Mil | Gwynn Jr, Tony | - Optioned to minors |
| 38 | 24 |
| 25-May | Mil | Branyan, Russ | + Purchased from minors |
| 39 | 25 |
| 26-May | Ari | Hammock, Robby | - Optioned to minors |
| 39 | 24 |
| 26-May | Ari | Tracy, Chad | + Activated from 15-day DL |
| 39 | 25 |
| 26-May | Atl | Resop, Chris | - Waived |
| 38 | 24 |
| 26-May | Atl | Carlyle, Buddy | + Activated from 15-day DL |
| 38 | 25 |
| 26-May | Cle | Hafner, Travis | - Injured |
| 40 | 24 |
| 26-May | Fla | de la Cruz, Eulogio | - Optioned to minors |
| 40 | 24 |
| 26-May | Fla | de Aza, Alejandro | - Transferred to 60-day DL |
| 39 | 24 |
| 26-May | Fla | Nelson, Joe | + Purchased from minors |
| 40 | 25 |
| 26-May | Hou | Nieve, Fernando | - Optioned to minors |
| 35 | 24 |
| 26-May | Hou | Cassel, Jack | + Recalled from minors |
| 35 | 25 |
| 26-May | LAA | Mosely, Dustin | + Activated from 15-day DL | and optioned | 40 | 24 |
| 26-May | NYY | Gonzalez, Alberto | - Optioned to minors |
| 40 | 24 |
| 26-May | NYY | Betemit, Wilson | + Activated from 15-day DL |
| 40 | 25 |
| 26-May | Oak | Devine, Joey | - Injured |
| 40 | 24 |
| 26-May | Tor | Zaun, Greg | - Injured |
| 40 | 24 |
| 26-May | Was | Zimmerman, Ryan | - Injured |
| 39 | 24 |
| 27-May | Ari | Byrnes, Eric | - Placed on 15-day DL |
| 39 | 24 |
| 27-May | Ari | Romero, Alex | + Recalled from minors |
| 39 | 25 |
| 27-May | Cin | Hatteberg, Scott | - Waived |
| 39 | 24 |
| 27-May | Cin | Bruce, Jay | + Purchased from minors |
| 40 | 25 |
| 27-May | Det | Sheffield, Gary | - Placed on 15-day DL |
| 36 | 24 |
| 27-May | Det | Larish, Jeff | + Purchased from minors |
| 37 | 25 |
| 27-May | Mil | Jackson, Zach | - Optioned to minors |
| 39 | 24 |
| 27-May | Mil | Tavarez, Julian | + Signed |
| 40 | 25 |
| 27-May | NYM | Wise, Matt | - Placed on 15-day DL |
| 38 | 24 |
| 27-May | NYM | Muniz, Carlos | + Recalled from minors |
| 38 | 25 |
| 27-May | Pit | Bixler, Brian | - Optioned to minors |
| 40 | 24 |
| 27-May | Pit | Wilson, Jack | + Activated from 15-day DL |
| 40 | 25 |
| 27-May | Tor | Luna, Hector | - Optioned to minors |
| 40 | 23 |
| 27-May | Tor | Eckstein, David | + Activated from 15-day DL |
| 40 | 24 |
| 28-May | Atl | Diaz, Matt | - Placed on 15-day DL |
| 38 | 24 |
| 28-May | Atl | Soriano, Rafael | + Activated from 15-day DL |
| 38 | 25 |
| 28-May | Bos | Matsuzaka, Daisuke | - Injured |
| 40 | 24 |
| 28-May | Cin | Patterson, Corey | - Optioned to minors |
| 40 | 24 |
| 28-May | Cin | Gonzalez, Alex | - Transferred to 60-day DL |
| 39 | 24 |
| 28-May | Cin | Phillips, Andy | + Purchased from minors |
| 40 | 25 |
| 28-May | Cle | Julio, Jorge | - Waived |
| 39 | 23 |
| 28-May | Cle | Westbrook, Jake | + Activated from 15-day DL |
| 39 | 24 |
| 28-May | Hou | Borkowski, Dave | - Waived |
| 34 | 24 |
| 28-May | Hou | Rodriguez, Wandy | + Activated from 15-day DL |
| 34 | 25 |
| 28-May | NYY | Kennedy, Ian | - Placed on 15-day DL |
| 40 | 24 |
| 28-May | NYY | Britton, Chris | + Recalled from minors |
| 40 | 25 |
| 28-May | Oak | Thomas, Frank | - Injured |
| 40 | 23 |
| 28-May | SD | Wells, Jared | - Traded to | Sea | 39 | 24 |
| 28-May | SD | Baek, Cha Seung | + Acquired from | waivers | 40 | 25 |
| 28-May | Sea | Wells, Jared | + Acquired from | SD and optioned | 38 | 25 |
| 28-May | StL | Pineiro, Joel | - Placed on 15-day DL |
| 40 | 24 |
| 28-May | StL | Jimenez, Kelvin | + Recalled from minors |
| 40 | 25 |
| 28-May | Tor | Zaun, Gregg | - Placed on 15-day DL |
| 40 | 24 |
| 28-May | Tor | Thigpen, Curtis | + Recalled from minors |
| 40 | 25 |
| 29-May | ChC | Ascanio, Jose | - Optioned to minors |
| 40 | 24 |
| 29-May | ChC | Cotts, Neal | + Recalled from minors |
| 40 | 25 |
| 29-May | ChW | Richar, Danny | + Activated from 15-day DL | and optioned | 39 | 25 |
| 29-May | Cin | Belisle, Matt | - Optioned to minors |
| 40 | 24 |
| 29-May | Cin | Mercker, Kent | + Activated from 15-day DL |
| 40 | 25 |
| 29-May | Cle | Westbrook, Jake | - Injured |
| 39 | 24 |
| 29-May | Det | Joyce, Matt | - Optioned to minors |
| 37 | 24 |
| 29-May | Det | Thomas, Clete | + Recalled from minors |
| 37 | 25 |
| 29-May | KC | Butler, Billy | - Optioned to minors |
| 39 | 24 |
| 29-May | KC | Nunez, Leo | - Placed on 15-day DL |
| 39 | 23 |
| 29-May | KC | Aviles, Mike | + Purchased from minors |
| 40 | 24 |
| 29-May | KC | Musser, Neal | + Recalled from minors |
| 40 | 25 |
| 29-May | Oak | Sweeney, Mike | - Injured |
| 40 | 22 |
| 29-May | Oak | Sweeney, Ryan | - Injured |
| 40 | 21 |
| 29-May | Oak | Thomas, Frank | - Placed on 15-day DL |
| 40 | 21 |
| 29-May | Oak | Fiorentino, Jeff | - Waived |
| 39 | 21 |
| 29-May | Oak | Chavez, Eric | + Activated from 60-day DL |
| 40 | 22 |
| 29-May | Pit | Salas, Marino | - Optioned to minors |
| 40 | 24 |
| 29-May | Pit | Bullington, Bryan | + Recalled from minors |
| 40 | 25 |
| 29-May | SD | Estes, Shawn | - Injured |
| 40 | 24 |
| 29-May | TB | Zobrist, Ben | - Optioned to minors |
| 38 | 24 |
| 29-May | TB | Percival, Troy | - Placed on 15-day DL |
| 38 | 23 |
| 29-May | TB | Aybar, Willie | + Activated from 15-day DL |
| 38 | 24 |
| 29-May | TB | Balfour, Grant | + Purchased from minors |
| 39 | 25 |
| 29-May | Tex | Loe, Kameron | - Optioned to minors |
| 38 | 24 |
| 29-May | Tex | Duran, German | - Optioned to minors |
| 38 | 23 |
| 29-May | Tex | Millwood, Kevin | + Activated from 15-day DL |
| 38 | 24 |
| 29-May | Tex | Metcalf, Travis | + Recalled from minors |
| 38 | 25 |
| 30-May | Atl | Kotsay, Mark | - Placed on 15-day DL |
| 38 | 24 |
| 30-May | Atl | Anderson, Josh | + Recalled from minors |
| 38 | 25 |
| 30-May | Bos | Jackson, Kyle | - Outrighted to minors |
| 39 | 24 |
| 30-May | Bos | Matsuzaka, Daisuke | - Placed on 15-day DL |
| 39 | 24 |
| 30-May | Bos | Bailey, Jeff | + Purchased from minors |
| 40 | 25 |
| 30-May | Cle | Hafner, Travis | - Placed on 15-day DL |
| 39 | 23 |
| 30-May | Cle | Choo, Shin-Soo | + Recalled from minors |
| 39 | 24 |
| 30-May | KC | Musser, Neal | - Optioned to minors |
| 40 | 24 |
| 30-May | KC | Hudson, Luke | - Transferred to 60-day DL |
| 39 | 24 |
| 30-May | KC | Pena, Brayan | + Acquired from | waivers | 40 | 25 |
| 30-May | LAA | Figgins, Chone | - Placed on 15-day DL |
| 40 | 24 |
| 30-May | LAA | Kendrick, Howie | + Activated from 15-day DL |
| 40 | 25 |
| 30-May | Min | Korecky, Bobby | - Optioned to minors |
| 40 | 24 |
| 30-May | Min | Neshek, Pat | - Transferred to 60-day DL |
| 39 | 24 |
| 30-May | Min | Breslow, Craig | + Acquired from | waivers | 40 | 25 |
| 30-May | Oak | Melillo, Kevin | - Outrighted to minors |
| 39 | 22 |
| 30-May | Oak | Sweeney, Ryan | - Placed on 15-day DL |
| 39 | 22 |
| 30-May | Oak | Sweeney, Mike | - Placed on 15-day DL |
| 39 | 22 |
| 30-May | Oak | Devine, Joey | - Placed on 15-day DL |
| 39 | 22 |
| 30-May | Oak | Dinardo, Lenny | - Waived |
| 38 | 21 |
| 30-May | Oak | Calero, Kiko | + Activated from 60-day DL |
| 39 | 22 |
| 30-May | Oak | Ziegler, Brad | + Purchased from minors |
| 40 | 23 |
| 30-May | Oak | Buck, Travis | + Recalled from minors |
| 40 | 24 |
| 30-May | Oak | Gonzalez, Carlos | + Recalled from minors |
| 40 | 25 |
| 30-May | SF | Ortmeier, Dan | - Placed on 15-day DL |
| 40 | 24 |
| 30-May | SF | Lowry, Noah | - Transferred to 60-day DL |
| 39 | 24 |
| 30-May | SF | Horwitz, Brian | + Purchased from minors |
| 40 | 25 |
| 30-May | StL | Duncan, Chris | - Optioned to minors |
| 40 | 24 |
| 30-May | StL | Mather, Joe | + Recalled from minors |
| 40 | 25 |
| 30-May | Tex | Gabbard, Kason | - Optioned to minors |
| 38 | 24 |
| 30-May | Tex | Nippert, Dustin | + Activated from 15-day DL | and outrighted | 37 | 24 |
| 30-May | Tex | Tejeda, Robinson | + Purchased from minors |
| 38 | 25 |
| 30-May | Tor | Hill, Aaron | - Injured |
| 40 | 24 |
| 31-May | Bos | Buchholz, Clay | + Activated from 15-day DL | and optioned | 40 | 25 |
| 31-May | ChW | Wise, DeWayne | - Waived |
| 38 | 24 |
| 31-May | ChW | Uribe, Juan | + Activated from 15-day DL |
| 38 | 25 |
| 31-May | Col | Newman, Josh | - Optioned to minors |
| 40 | 24 |
| 31-May | Col | Hirsh, Jason | - Transferred to 60-day DL |
| 39 | 24 |
| 31-May | Col | Rusch, Glendon | + Purchased from minors |
| 40 | 25 |
| 31-May | KC | Pena, Brayan | - Waived |
| 39 | 24 |
| 31-May | KC | Davies, Kyle | + Activated from 15-day DL |
| 39 | 25 |
| 31-May | Min | Clark, Howie | - Waived |
| 39 | 24 |
| 31-May | Min | Punto, Nick | + Activated from 15-day DL |
| 39 | 25 |
| 31-May | SD | Estes, Shawn | - Placed on 15-day DL |
| 40 | 24 |
| 31-May | SD | Guevara, Carlos | + Activated from 15-day DL |
| 40 | 25 |
| 31-May | StL | Jimenez, Kelvin | - Injured |
| 40 | 24 |
